Journal Sciences News
The Social Science Journal
July 2018
Editorial Board
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4

July 2018
Predictors of favorable outcome after mechanical thrombectomy for anterior circulation acute ischemic stroke in octogenarians
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Matthias Barral, Louis Lassalle, Cyril Dargazanli, Mikael Mazighi, Hocine Redjem, Raphael Blanc, Georges Rodesch, Bertrand Lapergue, Michel Piotin Introduction Mechanical thrombectomy for anterior circulation large vessel occlusion (LVO) improves functional outcome at three months. This therapeutic approach is the new gold standard, with a benefit being also observed in elderly patients. However, data are limited in this heterogeneous and fragile population. The objectives of this study were, first, to describe outcome after mechanical thrombectomy in a representative group of patients over 80. Second, to evaluate factors associated with a favorable functional outcome after thrombectomy for anterior circulation LVO in elderly patients (aged
July 2018
Ruptured extracranial carotid artery: Endovascular treatment with covered stent graft
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Ho Cheol Choi, Sung Eun Park, Dae Seob Choi, Hwa Seon Shin, Ji Eun Kim, Hye Young Choi, Mi Jung Park, Eun Ha Koh Background and purpose Rupture of the extracranial carotid artery is a rare, but potentially disastrous event. We aimed to review the clinical presentations and radiologic findings of this entity and to evaluate the efficacy of endovascular treatment with covered stent graft. Materials and methods Since January 2009, eight patients with extracranial carotid artery rupture received endovascular treatment with covered stent graft. We retrospectively reviewed their medical records and radiologic findings. Results The ruptured sites were in the common carotid artery (n =5), cervical ICA (n =2) and petrous ICA (n =1), respectively. The causes of injury included spontaneous (n =2), carotid blowout syndrome (CBS) (n =2), iatrogenic (n =2) and traumatic (n =2). Technical success and immediate hemostasis were achieved in all cases. Procedure-related complications occurred in 3 patients (37.5%). In a patient, the ipsilateral angular branch of the MCA was occluded during the procedure and it was completely reopened via mechanical thrombectomy without any neurologic deficit. Minor cerebral infarction was developed in 2 patients (25%). During a mean follow-up of 334 days (range 3–2053 days), two patients died: one from recurrent CBS and the other from aspiration pneumonia. Conclusions The covered stent grafting is an effective method for the treatment of extracranial carotid artery rupture.
July 2018
The angiographic and clinical outcomes of intracranial aneurysms following irradiation in patients with nasopharyngeal carcinoma: A 13-year experience and literature review
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Siang Hua Victor Chan, Yat Ming Peter Woo, Kai Sing Alain Wong, Kwong Yau Chan, Kar Ming Leung Background and purpose Intracranial aneurysms are a known but rare complication of radiotherapy (RT). We reviewed the angiographic and clinical outcomes of intracranial aneurysms following RT in patients with nasopharyngeal carcinoma (NPC), a malignancy endemic in Hong Kong. Materials and methods The clinical, angiographic and laboratory data was collected for nine NPC patients harboring fifteen intracranial aneurysms following RT, diagnosed between 1st January 2000 and 31st December 2012. Results The median age at aneurysm diagnosis was 56 years with a male predilection (67%). The median latent period to diagnosis was nine years (0.3–30). Eight patients (89%) presented with aneurysmal subarachnoid hemorrhage. Nine aneurysms were located at the anterior circulation, and 14 were saccular in morphology. Of the treated aneurysms, eight underwent endovascular intervention and two were surgically clipped. Within a year, 50% of the treated aneurysms had recurred. Poor neurological outcome was noted. At two-year follow-up, the median score for modified Rankin score and Glasgow Outcome score was 5 and 2 respectively. The two-year mortality rate of patients with treated ruptured intracranial aneurysms was 50%. Conclusion Compared to previous studies, our irradiated NPC patients had higher mortality and morbidity rates after aneurysm rupture and a higher angiographic recurrence rate following treatment. Greater vigilance is required in the detection of post-treatment recurrence of these aneurysms due to the higher risk of rupture. The authors recommend dedicated screening of intracranial aneurysms by active surveillance in routine CT protocols or the addition of three-dimensional time-of-flight magnetic resonance angiography in MR protocols.
July 2018
Multicenter initial experience with the EmboTrap device in acute anterior ischemic stroke
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): R. Bourcier, D. Abed, M. Piotin, H. Redjem, J.C. Ferr
July 2018
Apparent diffusion coefficient histogram analysis for prediction of prognosis in glioblastoma
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Masatoshi Kondo, Yoshikazu Uchiyama Background To investigate the potential to predict prognosis of glioblastoma (GBM) patients by analysis of the broader and lower values in the lower distribution of apparent diffusion coefficient (ADCL) (B&L-ADCL) values in the ADC histogram. Background Presurgical publicly available diffusion-weighted images (DWI) and contrast-enhanced T1-weighted images from 76 GBM patients were analyzed. With applied 2-mixture normal distribution in the ADC histogram of enhanced lesions on T1-weighted images, the mean and width of ADCL were analyzed. We dichotomized the lower mean of ADCL (L-ADCL) and the broader width of ADCL (B-ADCL) at their own average. B&L-ADCL was defined as B-ADCL with L-ADCL. Progression-free survival (PFS) and overall survival (OS) were determined by using Cox proportional hazards analysis and the Kaplan–Meier method with the log-rank test. The difference between PFS and OS was calculated. Results Six (7.89%) patients had B&L-ADCL values. B&L-ADCL was strongly associated with poor PFS (hazard risk: 5.747; P =0.002) and OS (hazard risk: 3.331; P =0.018). There were significant differences in PFS (median, 77 vs. 302 days; P <0.001) and OS (median, 199 vs. 472 days; P =0.004) between the patents with and without B&L-ADCL. There was no significant difference in the OS–PFS duration difference between the patients with (median, 79 days) and without B&L-ADCL (median, 132 days) (P =0.348). Conclusion In this study, B&L-ADCL from pretreatment ADC analysis predicted poor PFS. B&L-ADCL may indicate higher cellularity and heterogeneity in GBM tumor tissue.
July 2018
Meningioma assessment: Kinetic parameters in dynamic contrast-enhanced MRI appear independent from microvascular anatomy and VEGF expression
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Vera C. Keil, Bogdan Pintea, Gerrit H. Gielen, Kanishka Hittatiya, Angeliki Datsi, Matthias Simon, Rolf Fimmers, Hans H. Schild, Dariusch R. Hadizadeh Background and purpose Kinetic parameters of T1-weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) are considered to be influenced by microvessel environment. This study was performed to explore the extent of this association for meningiomas. Materials and methods DCE-MRI kinetic parameters (contrast agent transfer constants Ktrans and kep, volume fractions vp and ve) were determined in pre-operative 3T MRI of meningioma patients for later biopsy sites (19 patients; 15 WHO Io, no previous radiation, and 4 WHO IIIo pre-radiated recurrent tumors). Sixty-three navigated biopsies were consecutively retrieved. Biopsies were immunohistochemically investigated with endothelial marker CD34 and VEGF antibodies, stratified in a total of 4383 analysis units and computationally assessed for VEGF expression and vascular parameters (vessel density, vessel quantity, vascular fraction within tissue [vascular area ratio], vessel wall thickness). Derivability of kinetic parameters from VEGF expression or microvascularization was determined by mixed linear regression analysis. Tissue kinetic and microvascular parameters were tested for their capacity to identify the radiation status in a subanalysis. Results Kinetic parameters were neither significantly related to the corresponding microvascular parameters nor to tissue VEGF expression. There was no significant association between microvessel density and its presumed correlate vp (P =0.07). The subgroup analysis of high-grade radiated meningiomas showed a significantly reduced microvascular density (AUC 0.91; P <0.0001) and smaller total vascular fraction (AUC 0.73; P =0.01). Conclusions In meningioma, DCE-MRI kinetic parameters neither allow for a reliable prediction of tumor microvascularization, nor for a prediction of VEGF expression. Kinetic parameters seem to be determined from different independent factors.

Graphical abstract

image
July 2018
Altered functional connectivity of the subthalamic nucleus during self-initiated movement in Parkinson's disease
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Qian Jia, Linlin Gao, Jiarong Zhang, Tao Wu, Piu Chan Background and purpose Patients with Parkinson's disease (PD) have difficulty performing self-initiated movements. The neural mechanism of this deficiency remains unclear. In the present study, we used functional magnetic resonance imaging (fMRI) to investigate the functional connectivity of the subthalamic nucleus (STN) during self-initiated movement in patients with PD. Materials and methods fMRI were acquired from patients with PD and age- and sex-matched healthy control subjects during a self-initiated right hand tapping task. We selected the bilateral sensorimotor subregions of the STN as regions of interest for our connectivity analysis. Results and conclusions We found that the STN contralateral to voluntary hand movement exhibited enhanced connectivity with the midbrain, thalamus, putamen, and so on in patients with PD compared to control subjects. In contrast, the STN ipsilateral to the hand movement exhibited enhanced connectivity with the midbrain and insula in PD patients compared to control subjects. Connectivity between the STN contralateral to the hand movement and the primary motor cortex and supplementary motor area was positively correlated with the severity of bradykinesia. Our findings suggest that STN-related connectivity in the hyperdirect and indirect basal ganglia pathways is strengthened during self-initiated movement in patients with PD. These disrupted network connections may contribute to bradykinesia.
July 2018
Default-mode network and deep gray-matter analysis in neuromyelitis optica patients
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Fernanda C. Rueda-Lopes, Fernanda M.C. Pess
July 2018
Speculation on the naming of Moyamoya disease
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Mari Mori, Naoko Kurokawa, Gordon Worley
Available online 18 June 2018
Intraabdominal and Pelvic actinomycosis in association with posterior reversible encephalopathy syndrome (PRES): A case report
Publication date: July 2018
Source:Journal of Neuroradiology, Volume 45, Issue 4 Author(s): Sheng-Feng Lin, Tzu-I Wu, Chia-Lang Fang, Jing-Er Lee
Available online 18 June 2018
Main inherited neurodegenerative cerebellar ataxias, how to recognize them using magnetic resonance imaging?
Publication date: Available online 18 June 2018
Source:Journal of Neuroradiology Author(s): Damien Heidelberg, Solene Ronsin, Fabrice Bonneville, Salem Hannoun, Caroline Tilikete, Fran
Available online 18 June 2018
A quantitative and semi-automatic measurement of transverse sinus stenosis improves idiopathic intracranial hypertension diagnostic accuracy
Publication date: Available online 18 June 2018
Source:Journal of Neuroradiology Author(s): A. Pellerin, J. Aguilar Garcia, A. David, J. Meyer, B. Guyomarch Delasalle, S. De Gaalon, E. Auffray Calvier, H. Desal, R. Bourcier
Available online 18 June 2018
Deficiency of adenosine deaminase 2; special focus on central nervous system imaging
Publication date: Available online 18 June 2018
Source:Journal of Neuroradiology Author(s): Elif Bulut, Abdulsamet Erden, Omer Karadag, Kader Karli Oguz, Seza Ozen Purpose To increase the knowledge of central nervous system (CNS) imaging features in deficiency of adenosine deaminase 2 (DADA2) by examining magnetic resonance imaging (MRI) studies of a relatively large number of patients. Methods We retrospectively examined neuroimages of 12 patients (7 male, 5 female) diagnosed with DADA2. The mean age of the patients at the time of initial brain MRI was 16.7±10.2 years. Seven patients (58.3%) fulfilled the classification criteria of polyarteritis nodosa. Brain MRI studies were assessed with respect to findings of ischemia, intracranial hemorrhages, focal parenchymal signal abnormalities, cerebral/cerebellar volume loss, and abnormal contrast enhancement. Angiographic studies of 7 patients were evaluated for the signs of vasculitis. Results The most frequent finding was acute and/or chronic lacunar ischemic lesions in brain stem and/or deep gray matter (n=9, 75%). Six patients (50%) revealed MRI findings compatible with recurrent ischemic attacks. Small nodular contrast enhancement (n=2, 16.6%), acute putaminal hemorrhage (n=1, 8.3%) and findings compatible with posterior reversible encephalopathy syndrome (n=1, 8.3%) were also detected. Slight-to-moderate diffuse cerebral and/or cerebellar volume loss (n=7, 58.3%), decreased T1 signal of the bone marrow (n=6, 50%) and optic atrophy (n=1, 8.3%) were the other findings on brain MRI. The only abnormal angiographic finding was reduced caliber of right distal posterior cerebral artery detected in MRA of a patient (14.6%). Conclusion DADA2 should be included in the differential diagnosis of young patients presenting with ischemic and/or hemorrhagic lesions located in the brain stem and deep gray matter, especially if they have a family history or additional systemic abnormalities.
Available online 18 June 2018
Risk prediction of cerebrovascular events with carotid plaque magneitc resonance analysis: a meta-analysis
Publication date: Available online 18 June 2018
Source:Journal of Neuroradiology Author(s): Binghu Jiang, Dongmei He, Liwen Zhang, Min Ye Background and Purpose It is not conclusive that magnetic resonance (MR)-based carotid atherosclerotic plaque assessment identifies high-risk features associated with cerebrovascular events. We aimed to systematically summarize the association of MR imaging (MRI)-determined intraplaque hemorrhage (IPH), lipid-rich necrotic core (LRNC), and thinning/rupture of the fibrous cap (TRFC) with subsequent ischemic events. Materials and Methods We performed a comprehensive literature search evaluating the association of MRI-based carotid plaque composition with ischemic outcomes. We included cohort studies examining IPH, LRNC, or TRFC with mean follow-up of
Available online 21 May 2018
BAIL-OUT INTRACRANIAL STENTING WITH SOLITAIRE AB DEVICE AFTER UNSUCCESSFULL TROMBECTOMY IN ACUTE ISCHEMIC STROKE OF ANTERIOR CIRCULATION
Publication date: Available online 18 June 2018
Source:Journal of Neuroradiology Author(s): Sergio Nappini, Nicola Limbucci, Giuseppe Leone, Andrea Rosi, Leonardo Renieri, Arturo Consoli, Antonio Laiso, Iacopo Valente, Francesco Rosella, Riccardo Rosati, Salvatore Mangiafico Background Recent trials established the efficacy of mechanical stent-retriever thrombectomy for treatment of stroke patients with large vessel occlusion (LVO) in the anterior circulation. However, stent-retriever thrombectomy may not accomplish successful recanalization in all patients. The aim of this study is to report the role of bail-out permanent stenting after failure of mechanical thrombectomy. Methods Among 430 patients included in a prospectively maintained database, we analysed 325 cases of anterior circulation LVO. Mechanical thrombectomy (mTICI 2b-3) was effective in 213/325 (65%) and failed in 112/325 (35%). Bail-out intracranial stenting was performed in 17/325 (5.2%) patients. In all cases a fully retrievable detachable stent was used (Solitaire AB, Medtronic). Results No intraprocedural technical complications occurred. Successful reperfusion (mTICI 2b/3) was achieved in 12/17 patients (70.6%). Three (17.6%) patients died: one extensive infarction in the internal carotid artery territory, one large intracerebral haemorrhage, and one massive pulmonary embolism. Haemorrhagic conversion, both symptomatic and asymptomatic, occurred in 2/17 (11.7%). Good clinical outcome (mRS 0-2) at 3-months was achieved in 41.2% of patients. Conclusion Bail-out intracranial stenting after unsuccessful thrombectomy is technically feasible and the associated haemorrhagic risk seems acceptable in selected patients. We suggest that bail-out intracranial stenting, is safe and effective in selected patients with LVO stroke who failed to respond to thrombectomy.
Available online 9 May 2018
Consistency of normalized cerebral blood volume values in glioblastoma using different leakage correction algorithms on dynamic susceptibility contrast magnetic resonance imaging data without and with preload
Publication date: Available online 21 May 2018
Source:Journal of Neuroradiology Author(s): Dennis Hedderich, Anne Kluge, Thomas Pyka, Claus Zimmer, Jan S. Kirschke, Benedikt Wiestler, Christine Preibisch Background and purpose Several leakage correction algorithms for dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI)-based cerebral blood volume (CBV) measurement have been proposed, and combination with a preload of contrast agent is generally recommended. A single bolus application scheme would largely simplify and facilitate standardized clinical applications, while reducing contrast agent (CA) dose. The aim of this study was, therefore, to investigate whether appropriate leakage correction redundantizes prebolus application by comparing normalized DSC-based CBV (nCBV) measures of two consecutive CA boli. Materials and methods Twenty-seven patients with suspected glioblastoma (WHO-grade-IV) underwent DSC-MRI during two consecutive boli of Gd-based CA. Four variants of two post-processing leakage correction techniques were compared with respect to nCBV in contrast enhancing tumor tissue. First, a reference curve approach with first pass and full integration of corrected
Available online 9 May 2018
Can dynamic contrast-enhanced MRI evaluate VEGF expression in brain glioma? An MRI-guided stereotactic biopsy study
Publication date: Available online 9 May 2018
Source:Journal of Neuroradiology Author(s): Ningning Di, Wenna Cheng, Xingyue Jiang, Xinjiang Liu, Jinliang Zhou, Qian Xie, Zhihui Chu, Huacheng Chen, Bin Wang Purpose To investigate whether pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to evaluate vascular endothelial growth factor (VEGF) expression in brain glioma based on a point-to-point basis. Materials and methods Forty-seven patients with treatment-na
Available online 4 May 2018
High-resolution magnetic resonance vessel wall imaging of chronic intracranial internal carotid artery occlusion
Publication date: Available online 9 May 2018
Source:Journal of Neuroradiology Author(s): Xiangyan Chen, Wenjie Yang, Chiu Wing Chu, Ka Sing Wong, Thomas Wai Hong Leung
Available online 4 May 2018
Disruptions of brain structural network in end-stage renal disease patients with long-term hemodialysis and normal-appearing brain tissues
Publication date: Available online 4 May 2018
Source:Journal of Neuroradiology Author(s): Ming-Chung Chou, Chih-Hung Ko, Jer-Ming Chang, Tsyh-Jyi Hsieh Objective End-stage renal disease (ESRD) patients on hemodialysis were demonstrated to exhibit silent and invisible white-matter alterations which would likely lead to disruptions of brain structural networks. Therefore, the purpose of this study was to investigate the disruptions of brain structural network in ESRD patients. Materials and Methods Thiry-three ESRD patients with normal-appearing brain tissues and 29 age- and gender-matched healthy controls were enrolled in this study and underwent both cognitive ability screening instrument (CASI) assessment and diffusion tensor imaging (DTI) acquisition. Brain structural connectivity network was constructed using probabilistic tractography with automatic anatomical labeling template. Graph-theory analysis was performed to detect the alterations of node-strength, node-degree, node-local efficiency, and node-clustering coefficient in ESRD patients. Correlational analysis was performed to understand the relationship between network measures, CASI score, and dialysis duration. Results Structural connectivity, node-strength, node-degree, and node-local efficiency were significantly decreased, whereas node-clustering coefficient was significantly increased in ESRD patients as compared with healthy controls. The disrupted local structural networks were generally associated with common neurological complications of ESRD patients, but the correlational analysis did not reveal significant correlation between network measures, CASI score, and dialysis duration. Conclusion Graph-theory analysis was helpful to investigate disruptions of brain structural network in ESRD patients with normal-appearing brain tissues.
Available online 4 May 2018
Complication rate of intraarterial treatment of severe cerebral vasospasm after subarachnoid hemorrhage with nimodipine and percutaneous transluminal balloon angioplasty: Worth the risk?
Publication date: Available online 4 May 2018
Source:Journal of Neuroradiology Author(s): Daniela Adami, Joachim Berkefeld, Johannes Platz, J
Available online 4 May 2018
Evaluation of the apparent diffusion coefficient in patients with recurrent glioblastoma under treatment with bevacizumab with radiographic pseudoresponse
Publication date: Available online 4 May 2018
Source:Journal of Neuroradiology Author(s): Timo A. Auer, Hanns-Christian Breit, Federico Marini, Mirjam Renovanz, Marc A. Brockmann, Yasemin Tanyildizi Background Response Assessment in Neuro-Oncology Criteria (RANO), are used to asses response to first-line treatment of glioblastoma (GBM). Differentiation between response and pseudoresponse under treatment with Bevacizumab (BVZ) remains challenging. This study evaluates ADC changes in patients with radiographic pseudoresponse under treatment with (BVZ). Methods Patients (n =40) with recurrent GBM under-treatment with BVZ underwent MRI before, two and four months after treatment with BVZ. In patients with radiological pseudoresponse (n =11), ADC analyses were performed. Areas with decreasing T1 contrast enhancement (CE) and FLAIR signal decrease were manually selected and compared to size and position matched healthy contralateral brain parenchyma. Results Histogram based ADC (10–6
May 2018
Clinical equivalence assessment of T2 synthesized pediatric brain magnetic resonance imaging
Publication date: Available online 4 May 2018
Source:Journal of Neuroradiology Author(s): Basile Kerleroux, Tobias Kober, Tom Hilbert, Maxence Serru, Jean Philippe, Dominique Sirinelli, Baptiste Morel Background and purpose Automated synthetic magnetic resonance imaging (MRI) provides qualitative, weighted image contrasts as well as quantitative information from one scan and is well-suited for various applications such as analysis of white matter disorders. However, the synthesized contrasts have been poorly evaluated in pediatric applications. The purpose of this study was to compare the image quality of synthetic T2 to conventional turbo spin-echo (TSE) T2 in pediatric brain MRI. Materials and methods This was a mono-center prospective study. Synthetic and conventional MRI acquisitions at 1.5 Tesla were performed for each patient during the same session using a prototype accelerated T2 mapping sequence package (TAsynthetic =3:07min, TAconventional =2:33min). Image sets were blindly and randomly analyzed by pediatric neuroradiologists. Global image quality, morphologic legibility of standard structures and artifacts were assessed using a 4-point Likert scale. Inter-observer kappa agreements were calculated. The capability of the synthesized contrasts and conventional TSE T2 to discern normal and pathologic cases was evaluated. Results Sixty patients were included. The overall diagnostic quality of the synthesized contrasts was non-inferior to conventional imaging scale (P =0.06). There was no significant difference in the legibility of normal and pathological anatomic structures of synthetized and conventional TSE T2 (all P >0.05) as well as for artifacts except for phase encoding (P =0.008). Inter-observer agreement was good to almost perfect (kappa between 0.66 and 1). Conclusions T2 synthesized contrasts, which also provides quantitative T2 information that could be useful, could be suggested as an equivalent technique in pediatric neuro-imaging, compared to conventional TSE T2.
May 2018
Editorial Board
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3

May 2018
Encoding and immediate retrieval tasks in patients with epilepsy: A functional MRI study of verbal and visual memory
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): Najat Saddiki, Sophie Hennion, Romain Viard, Nassima Ramdane, Renaud Lopes, Marc Baroncini, William Szurhaj, Nicolas Reyns, Jean Pierre Pruvo, Christine Delmaire Purpose Medial lobe temporal structures and more specifically the hippocampus play a decisive role in episodic memory. Most of the memory functional magnetic resonance imaging (fMRI) studies evaluate the encoding phase; the retrieval phase being performed outside the MRI. We aimed to determine the ability to reveal greater hippocampal fMRI activations during retrieval phase. Materials and methods Thirty-five epileptic patients underwent a two-step memory fMRI. During encoding phase, subjects were requested to identify the feminine or masculine gender of faces and words presented, in order to encourage stimulus encoding. One hour after, during retrieval phase, subjects had to recognize the word and face. We used an event-related design to identify hippocampal activations. Results There was no significant difference between patients with left temporal lobe epilepsy, patients with right temporal lobe epilepsy and patients with extratemporal lobe epilepsy on verbal and visual learning task. For words, patients demonstrated significantly more bilateral hippocampal activation for retrieval task than encoding task and when the tasks were associated than during encoding alone. Significant difference was seen between face-encoding alone and face retrieval alone. Conclusions This study demonstrates the essential contribution of the retrieval task during a fMRI memory task but the number of patients with hippocampal activations was greater when the two tasks were taken into account.
May 2018
Automated brain tissue and myelin volumetry based on quantitative MR imaging with various in-plane resolutions
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): C. Andica, A. Hagiwara, M. Hori, M. Nakazawa, M. Goto, S. Koshino, K. Kamagata, K.K. Kumamaru, S. Aoki Background and purpose Segmented brain tissue and myelin volumes can now be automatically calculated using dedicated software (SyMRI), which is based on quantification of R1 and R2 relaxation rates and proton density. The aim of this study was to determine the validity of SyMRI brain tissue and myelin volumetry using various in-plane resolutions. Methods We scanned 10 healthy subjects on a 1.5T MR scanner with in-plane resolutions of 0.8, 2.0 and 3.0mm. Two scans were performed for each resolution. The acquisition time was 7-min and 24-sec for 0.8mm, 3-min and 9-sec for 2.0mm and 1-min and 56-sec for 3.0mm resolutions. The volumes of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), non-WM/GM/CSF (NoN), brain parenchymal volume (BPV), intracranial volume (ICV) and myelin were compared between in-plane resolutions. Repeatability for each resolution was then analyzed. Results No significant differences in volumes measured were found between the different in-plane resolutions, except for NoN between 0.8mm and 2.0mm and between 2.0mm and 3.0mm. The repeatability error value for the WM, GM, CSF, NoN, BPV and myelin volumes relative to ICV was 0.97%, 1.01%, 0.65%, 0.86%, 1.06% and 0.25% in 0.8mm; 1.22%, 1.36%, 0.73%, 0.37%, 1.18% and 0.35% in 2.0mm and 1.18%, 1.02%, 0.96%, 0.45%, 1.36%, and 0.28% in 3.0mm resolutions. Conclusion SyMRI brain tissue and myelin volumetry with low in-plane resolution and short acquisition times is robust and has a good repeatability so could be useful for follow-up studies.
May 2018
CNS aspergilloma mimicking tumors: Review of CNS aspergillus infection imaging characteristics in the immunocompetent population
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): Devendra Kumar, Pankaj Nepal, Sumit Singh, Subramaniyan Ramanathan, Maneesh Khanna, Rakesh Sheoran, Sanjay Kumar Bansal, Santosh Patil Background and purpose CNS Aspergillosis is very rare and difficult to diagnose clinically and on imaging. Our objective was to elucidate distinct neuroimaging pattern of CNS aspergillosis in the immunocompetent population that helps to differentiate from other differential diagnosis. Methods Retrospective analysis of brain imaging findings was performed in eight proven cases of central nervous system aspergillosis in immunocompetent patients. Immunocompetent status was screened with clinical and radiological information. Cases were evaluated for anatomical distribution, T1 and T2 signal pattern in MRI and attenuation characteristics in CT scan, post-contrast enhancement pattern, internal inhomogeneity, vascular involvement, calvarial involvement and concomitant paranasal, cavernous sinus or orbital extension. All patients were operated and diagnosis was confirmed on histopathology. Results The age range was 19–50 years with mean age of 33.7 years. Concomitant sinonasal disease was seen in six patients (75%). Three patients had orbital extensions. Most of the lesions (n =7) were profoundly hypointense in T2-weighted imaging. The most common enhancement pattern was bright, solid and homogenous enhancement (n =7). Cavernous extension with ICA encasement was always associated with paranasal sinus disease. Six patients showed demineralization or complete resorption of involved bone. All of the fungal masses appear hyperdense on available CT scan images. Conclusion CNS aspergillus infection in immunocompetent patients has distinct imaging features as compared to CNS aspergillosis in immunocompromised patients. A high index of suspicion in proper clinical settings, even with immunocompetent status and typical imaging features allow us to diagnose CNS aspergillosis in such patients.
May 2018
A new time-resolved 3D angiographic technique (4D DSA): Description, and assessment of its reliability in Spetzler–Martin grading of cerebral arteriovenous malformations
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): Julien Ognard, Elsa Magro, Jildaz Caroff, Douraied Ben Salem, Sebastien Andouard, Michel Nonent, Jean-Christophe Gentric Background and purpose The Spetzler and Martin (SM) cerebral arteriovenous malformation (AVM) classification is a widely used 5-tier classification. This common language allows specialists to exchange about AVMs and must be reliably characterized by the imaging methods. We presented an agreement study on a new method of digital subtracted 3D rotational angiography resolved in time (four-dimensional DSA: 4D DSA) compared to the gold standard (two-dimensional DSA: 2D DSA) in AVM grading using the SM classification. Methods Ten patients with AVMs were included during one year, they had an angiographic exploration with both 4D DSA and 2D DSA. Three readers assessed the SM classification. One reader conducted a second reading. The inter-, intra-observer and intermodality agreements were calculated by Kappas. Dose to patient was reported. Results Considering the SM grade, the inter-observer agreement between 4D DSA and 2D DSA was equivalent (
May 2018
Feasibility of improved motion-sensitized driven-equilibrium (iMSDE) prepared 3D T1-weighted imaging in the diagnosis of vertebrobasilar artery dissection
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): Jin Wook Choi, Miran Han, Ji Man Hong, Jin Soo Lee, Sun Yong Kim, Sam Soo Kim Background and purpose This study was to evaluate the diagnostic value of improved motion-sensitized driven-equilibrium (iMSDE)-prepared 3D T1-weighted magnetic resonance imaging (MRI) (iMSDE-3DMRI) in intracranial vertebrobasilary dissection (VBD) and to compare iMSDE-3DMRI images with those obtained using 2D high-resolution (HR) MRI with respect to their diagnostic performance in VBD. Materials and methods We retrospectively reviewed 105 lesions from 102 patients who underwent multimodal imaging and contrast-enhanced iMSDE-3DMRI (CE-iMSDE-3DMRI). The 2D-HRMRI protocol comprised four axial HR images. The CE-iMSDE-3DMRI images were reformatted in the axial, coronal, and sagittal planes. The 2D-HRMRI-based diagnosis was compared with the final diagnosis. The 2D-HRMRI and CE-iMSDE-3DMRI images were examined independently for the diagnosis performance of dissection. Results VBD was confirmed in 66 lesions in 63 patients; 17 patients had confirmed atherosclerosis, and 22 had no lesions in the vertebrobasilar artery. Diagnostic performances of 2D-HRMRI (AUC, 0.839±0.04; sensitivity, 94.0; specificity, 79.5; diagnostic accuracy, 88.6) CE-iMSDE-3DMRI (AUC, 0.847±0.04; sensitivity, 84.8; specificity, 84.6; diagnostic accuracy, 84.7) and 2D-HRMRI+CE-iMSDE-3DMRI (AUC, 0.893±0.03; sensitivity, 97.0; specificity, 85.0; diagnostic accuracy, 92.5) were good. Comparisons of the diagnostic performance of 2D-HRMRI andCE-iMSDE-3DMRI showed that combined interpretation of 2D-HRMRI and iMSDE-3DMRI yields a significantly higher diagnostic performance than that of 2D-HRMRI (P =0.042). Conclusions CE-iMSDE-3DMRI showed good diagnostic performance for the diagnosis of intracranial VBD. These results suggest that CE-iMSDE-3DMRI can be used in combination with 2D-HRMRI for the diagnosis of intracranial VBD.
May 2018
Variability of stroke patients meeting endovascular stroke trial criteria in a non-clinical trial setting
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): Jennifer E. Fugate, Waleed Brinjikji, Harry Cloft, David F. Kallmes, Alejandro A. Rabinstein Background Five randomized trials proving the efficacy and safety of mechanical embolectomy for ischemic stroke within 8hours used differing radiological methods to select patients. We aimed to evaluate the proportion of patients in clinical practice that would meet radiological criteria for inclusion in these trials. Methods Retrospective study of ischemic stroke patients at a large academic medical center who were considered for endovascular stroke therapy based on confirmed intracranial large vessel occlusion from April 2010–November 2014. All patients underwent computed tomography (CT) perfusion and CT angiogram. Results Of 119 patients, median age was 69 years (IQR 57–79) and median NIHSS 18 (IQR 14–21). Most patients had ASPECTS
May 2018
Endovascular management of extracranial occlusions at the hyperacute phase of stroke with tandem occlusions
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): M.-A. Labeyrie, C. Ducroux, V. Civelli, P. Reiner, E. Cognat, A. Aymard, A. Bisdorff, J.-P. Saint-Maurice, E. Houdart Background and purpose The management of cervical artery occlusions in hyperacute stroke with tandem cervical/intracranial occlusions has not yet become standardized, especially when the circle of Willis is effective. Methods We retrospectively analyzed the safety and accuracy of current approaches to manage the cervical occlusion in consecutive patients with tandem occlusions addressed for intracranial mechanical thrombectomy (MT) in our department from January 2012 to May 2017. The different approaches that could be performed in a same patient during the same procedure or hospitalization were analyzed separately. Results We reported 64 approaches to manage the cervical occlusion in 49 patients with tandem occlusion (14% of MT): medical treatment alone in 16/64 (25%), stenting/angioplasty in 16/64 (25%), occlusion with coils in 12/64 (19%), angioplasty alone in 9/64 (14%), stent-retriever in 8/64 (12%), and/or thromboaspiration in 3/64 (5%). Early ipsilateral embolic recurrence occurred after 9/64 (14%) of them. It was strongly associated with the presence of a cervical intraluminal thrombus (P =0.001) and was then lower after occlusion with coils and stent-retriever compared to medical treatment alone and thromboaspiration (P=0.002). Occlusion with coils had a lower rate of radiological intracranial hemorrhage at 48-hour compared to other approaches (P =0.009). The 3-month rates of favorable outcome (P =0.806) and mortality (P =0.878) were similar. One delayed stroke was imputable to an occlusion with coils, for a median (Q1–Q3) follow-up of 10 (3–20) months. Conclusions Cervical occlusion with coils and thrombectomy with stent-retrievers may be relevant to prevent early embolic recurrence in cervical occlusions with intraluminal thrombus. Stent-retrievers should be further assessed as a first-line approach, since delayed stroke may occur following occlusion with coils. Medical treatment alone may be sufficient when no cervical intraluminal thrombus is present, the Willis polygon is effective, and the cervical occlusion can be crossed easily to perform the intracranial thrombectomy.
May 2018
Trans-venous embolization of a basal ganglia ruptured arteriovenous malformation with open surgical arterial control: A hybrid technique
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): Zsolt Kulcs
Available online 3 April 2018
Newly observed anterior thalamocortical fiber of the thalamus using 7.0T super-resolution magnetic resonance tractography and its implications for the classical Papez circuit
Publication date: May 2018
Source:Journal of Neuroradiology, Volume 45, Issue 3 Author(s): Sang-Han Choi, Young-Bo Kim, Zang-Hee Cho Here, we have employed recently developed super-resolution tractography using 7.0T-MRI to analyze the fine structures involved in thalamocortical connections, something that has proved difficult using conventional techniques. We detail a newly observed thalamocortical pathway connecting the anterior nucleus of the thalamus and the cingulate cortex not via the internal capsule but via the septal area. The observed pathway is believed to be a classical pathway of the Papez circuit but had not been previously identified.
Available online 3 April 2018
Experimental evaluation of the NeVa™ thrombectomy device a novel stent retriever conceived to improve efficacy of organized clot removal
Publication date: Available online 3 April 2018
Source:Journal of Neuroradiology Author(s): Paolo Machi, Arthur J. Ulm, Gianmarco Bernava, Olivier Brina, Karl Olof Lovblad, Franck Jourdan Background and purpose Stent retrievers are recognized as the most effective devices for intracranial thrombectomy. Although highly effective, such devices fail in clot removal when the brain vessel occlusion is due to organized, firm clots. The mechanism of failure is that during the retrieval, devices remain compressed by the organized clot and slide between it and the vessel wall without any removal effect. The aim of the current study is to present the preclinical evaluation of the Neva™ device, a novel stent retriever designed to improve the incorporation and removal of organized thrombi. Materials and methods Preclinical evaluation of the Neva™ device was divided in three main chapters: efficacy analysis, mechanical analysis and safety analysis. Efficacy and mechanical analysis aimed to investigate the behavior during the retrieval of the Neva™ device and its interaction with experimental organized clots. Safety analysis was conducted on animals in order to investigate the effect of the Neva™ device on real arteries after simulated thrombectomy maneuvers. Results Neva™ device showed a high rate of “optimal clot integration” and “effective clot removal” which was related to constant cohesion to the vessel wall during retrievals. Safety analysis showed as the most frequent finding the disruption of the intima of the tested vessels with, in some cases, minimal disruption of the internal elastic lamina. Conclusions The Neva™ device has demonstrated safety and efficacy in a pre-clinical study. Such encouraging, preliminary results have to be compared with those of clinical trials.
Available online 28 March 2018
Brain CT perfusion improves intracranial vessel occlusion detection on CT angiography
Publication date: Available online 3 April 2018
Source:Journal of Neuroradiology Author(s): Marinus J. Becks, Rashindra Manniesing, Jeroen Vister, Sjoert A.H. Pegge, Stefan C.A. Steens, Ewoud J. van Dijk, Mathias Prokop, Frederick J.A. Meijer Background and purpose To evaluate whether brain CT perfusion (CTP) aids in the detection of intracranial vessel occlusion on CT angiography (CTA) in acute ischemic stroke. Materials and methods Medical-ethical committee approval of our hospital was obtained and informed consent was waived. Patients suspected of acute ischemic stroke who underwent non-contrast CT(NCCT), CTA and whole-brain CTP in our center in the year 2015 were included. Three observers with different levels of experience evaluated the imaging data of 110 patients for the presence or absence of intracranial arterial vessel occlusion with two strategies. In the first strategy, only NCCT and CTA were available. In the second strategy, CTP maps were provided in addition to NCCT and CTA. Receiver-operating-characteristic (ROC) analysis was used for the evaluation of diagnostic accuracy. Results Overall, a brain perfusion deficit was scored present in 87–89% of the patients with an intracranial vessel occlusion, more frequently observed in the anterior than in the posterior circulation. Performance of intracranial vessel occlusion detection on CTA was significantly improved with the availability of CTP maps as compared to the first strategy (P =0.023), due to improved detection of distal and posterior circulation vessel occlusions (P-values of 0.032 and 0.003 respectively). No added value of CTP was found for intracranial proximal vessel occlusion detection, with already high accuracy based on NCCT and CTA alone. Conclusion The performance of intracranial vessel occlusion detection on CTA was improved with the availability of brain CT perfusion maps due to the improved detection of distal and posterior circulation vessel occlusions.
Available online 28 March 2018
Characteristic phase distribution in the white matter of infants on phase difference enhanced imaging
Publication date: Available online 28 March 2018
Source:Journal of Neuroradiology Author(s): Tesu Niwa, Tetsuya Yoneda, Masaharu Hayashi, Keiji Suzuki, Shuhei Shibukawa, Takashi Okazaki, Yutaka Imai Background and purpose The infantile brain is continuously undergoing development. Non-invasive methods to assess the neurological development of infants are important for the early detection of abnormalities. Some microstructures in the brain have been demonstrated via phase difference-enhanced imaging (PADRE), which may reflect myelin-related microstructures. We aimed to assess the white matter (WM) signal distribution in infants using PADRE and compared it with that using T1-weighted images (T1WI) and diffusion tensor imaging (DTI) on magnetic resonance imaging (MRI). Materials and method This study included 18 infants (postmenstrual age at MRI, 37–40 weeks) without abnormal findings on MRI. Signal distribution using T1WI, a fractional anisotropy (FA) map and PADRE was assessed regarding the following intraparenchymal structures: the optic radiation (OR), internal capsule (IC), corpus callosum, corticospinal tract (CST), semiovale center and subcortical regions. Results We found that the signal distribution was significantly different (P <0.001) with a relatively large signal change found at the IC and CST across the three imaging methods. Signal changes were also greater at the OR and rolandic subcortical WM on PADRE, whereas these were smaller on T1WI and FA. Conclusion PADRE demonstrated a characteristic phase shift distribution in infantile WM, which was different from that observed on T1WI and FA maps, and may demonstrate the developing myelin-related structures. PADRE can be a unique indicator of infantile brain development.
Available online 12 March 2018
Effect of blood T1 estimation strategy on arterial spin labeled cerebral blood flow quantification in children and young adults with kidney disease
Publication date: Available online 28 March 2018
Source:Journal of Neuroradiology Author(s): Hua-Shan Liu, Abbas F. Jawad, Nina Laney, Erum A. Hartung, Susan L. Furth, John A. Detre Purpose To compare blood T1 estimation approaches used for quantifying cerebral blood flow (CBF) with arterial spin labeled (ASL) perfusion MRI in a developmental cohort of chronic kidney disease (CKD) patients with anemia and a control group. Methods 61 patients with CKD and 47 age-matched control subjects were studied. Blood T1 approaches included: (1) a fixed value, (2) estimation based on measured hematocrit (Hct), and (3) estimation based on Age+Sex using a published formula. Resulting T1 and CBF values were compared along with group, age and sex effects. Results Highly significant group differences in CBF using fixed blood T1 were reduced when Hct-corrected blood T1 was used, and were eliminated entirely when using the Age+Sex estimated approach. In the control cohort, fixed T1 method showed the strongest correlations of CBF with age and sex. Hct-corrected T1 preserved a significant correlation between CBF and age and sex, while Age+Sex estimated T1 produced a poor fit of CBF with age and sex. Conclusions Blood T1 estimation method can confound the interpretation of CBF changes measured using ASL MRI in patients with CKD. Blood T1 should ideally be corrected for hematocrit effects in clinical populations with anemia.
Available online 7 March 2018
Evaluation of safety, efficacy and clinical outcome after endovascular treatment of aneurysmal subarachnoid hemorrhage in coil-first setting. A 10-year series from a single center
Publication date: Available online 12 March 2018
Source:Journal of Neuroradiology Author(s): Muhammad AlMatter, Pervinder Bhogal, Marta Aguilar P
Available online 7 March 2018
CT angiography for one-year follow-up of intracranial aneurysms treated with the WEB device: Utility in evaluating aneurysm occlusion and WEB compression at one year
Publication date: Available online 7 March 2018
Source:Journal of Neuroradiology Author(s): H
Available online 7 March 2018
Objective evaluation of cerebrovascular reactivity for acetazolamide predicts cerebral hyperperfusion after carotid artery stenting: Comparison with region of interest methods
Publication date: Available online 7 March 2018
Source:Journal of Neuroradiology Author(s): Kouichi Misaki, Naoyuki Uchiyama, Anri Inaki, Seigo Kinuya, Iku Nambu, Tomoya Kamide, Masanao Mohri, Yasuhiko Hayashi, Mitsutoshi Nakada Background and purpose Hemodynamic impairments are considered risk factors of cerebral hyperperfusion after carotid artery stenting (CAS); measurement by Single-photon emission computed tomography (SPECT) using a subjective region of interest (ROI) method lacks consistency and reproducibility. Materials and methods The present study compared objective perfusion analysis (stereotactic extraction estimation [SEE] method) with the ROI method for preoperative SPECT to predict the hyperperfusion phenomenon (HPP) after CAS. Preoperative resting asymmetry index (cerebral blood flow [CBF] ratio from the affected to unaffected hemisphere) and cerebrovascular reactivity (CVR) to acetazolamide were measured by N-isopropyl-p-[123I]-iodoamphetamine SPECT using the SEE and ROI method in 84 patients. CBF was also measured the day after CAS. Perfusion data with the highest area under the curve (AUC) by receiver-operating characteristic (ROC) analysis was considered a perfusion risk factor of HPP. Multivariate analyses for clinical characteristics and perfusion risk factors were performed to determine predictors of HPP. Results The HPP was observed in 10 patients (11.9%). Female sex, contralateral stenosis, and degree of stenosis were significantly associated with HPP development on univariate analysis, and symptomatic stenosis was not found to be a significant factor. On SPECT analysis, CVR in the MCA area by SEE method had the highest AUC (0.981). Multivariate analysis showed that CVR in the MCA area was a significant predictor of HPP (P =0.041). To predict hyperperfusion, the ROC curve of the CVR showed a cutoff value of –0.60%, sensitivity of 94.6%, and specificity of 100% (P <0.001). Conclusions Objective SEE method had better a predictive capability than ROI method to identify risk of hyperperfusion after CAS.
Available online 2 March 2018
Postoperative in-stent protrusion is an important predictor of perioperative ischemic complications after carotid artery stenting
Publication date: Available online 7 March 2018
Source:Journal of Neuroradiology Author(s): Mikiya Beppu, Yohei Mineharu, Hirotoshi Imamura, Hidemitsu Adachi, Chiaki Sakai, Shoichi Tani, Koichi Arimura, So Tokunaga, Nobuyuki Sakai Background and purpose Although in-stent protrusion is a potential risk factor for thromboembolism following carotid artery stenting, the correlation between in-stent protrusion and postoperative ipsilateral stroke has not been well examined. Materials and methods We retrospectively reviewed 342 consecutive carotid artery lesions in 319 patients who underwent carotid artery stenting between April 2008 and April 2015. After excluding cases with carotid artery dissection and acute occlusion, 301 lesions in total of 277 patients were included in the analysis. We examined the association between in-stent protrusion, which was detected by intravascular ultrasound, and postoperative ipsilateral stroke within 30 days. Results In-stent protrusion was observed in 47 (15.6%) lesions, of which postoperative ipsilateral stroke within 30 days occurred with 4 (8.5%) lesions. All these events occurred within 10 days after treatment. On the other hand, only 1 (0.39%) of the 256 lesions without in-stent protrusion showed this symptom, and the event occurred at 30days after treatment. Thus, lesions with in-stent protrusion had a higher cumulative risk of ipsilateral stroke than those without in-stent protrusion (8.5% vs 0.4% at 30 days, log-rank P < 0.001). In-stent protrusion, which was more often seen in symptomatic lesions, was associated with a vulnerable plaque assessed by MRI. After adjustment for postoperative stroke risks such as symptomatic lesions, plaque vulnerability, age or sex, in-stent protrusion was still significantly associated with postoperative ipsilateral stroke within 30 days (OR = 27.03, P = 0.001). Conclusions Postoperative ipsilateral stroke was observed more frequently in patients with demonstrated in-stent protrusion (ISP) following CAS.
Available online 2 March 2018
Radiotherapy in acromegaly: Long-term brain parenchymal and vascular magnetic resonance changes
Publication date: Available online 2 March 2018
Source:Journal of Neuroradiology Author(s): Laura Milanese, Chiara Martini, Carla Scaroni, Francesca Dassie, Filippo Ceccato, Alessandro Della Puppa, Luca Denaro, Giulia Bommarito, Valentina Citton, Mario Ermani, Pietro Maffei, Renzo Manara Background Radiation therapy (RT) effectiveness on hormonal reduction is proven in acromegaly; however, collateral long-term effects are still undetermined. This transversal neuroimaging study on a large cohort of acromegalic patients aimed to investigate the rate of parenchymal and vascular changes after RT. Materials and methods Thirty-six acromegalic patients underwent RT (RT+) after unsuccessful surgery and were compared to RT
Available online 2 March 2018
Historadiological correlations in high-grade glioma with the histone 3.3 G34R mutation
Publication date: Available online 2 March 2018
Source:Journal of Neuroradiology Author(s): Julien Puntonet, Volodia Dangouloff-Ros, Rapha
Available online 2 March 2018
Evaluation of prospective motion correction of high-resolution 3D-T2-FLAIR acquisitions in epilepsy patients
Publication date: Available online 2 March 2018
Source:Journal of Neuroradiology Author(s): Sjoerd B. Vos, Caroline Micallef, Frederik Barkhof, Andrea Hill, Gavin P. Winston, Sebastien Ourselin, John S. Duncan T2-FLAIR is the single most sensitive MRI contrast to detect lesions underlying focal epilepsies but 3D sequences used to obtain isotropic high-resolution images are susceptible to motion artefacts. Prospective motion correction (PMC) – demonstrated to improve 3D-T1 image quality in a pediatric population – was applied to high-resolution 3D-T2-FLAIR scans in adult epilepsy patients to evaluate its clinical benefit. Coronal 3D-T2-FLAIR scans were acquired with a 1mm isotropic resolution on a 3T MRI scanner. Two expert neuroradiologists reviewed 40 scans without PMC and 40 with navigator-based PMC. Visual assessment addressed six criteria of image quality (resolution, SNR, WM-GM contrast, intensity homogeneity, lesion conspicuity, diagnostic confidence) on a seven-point Likert scale (from non-diagnostic to outstanding). SNR was also objectively quantified within the white matter. PMC scans had near-identical scores on the criteria of image quality to non-PMC scans, with the notable exception that intensity homogeneity was generally worse. Using PMC, the percentage of scans with bad image quality was substantially lower than without PMC (3.25% vs. 12.5%) on the other five criteria. Quantitative SNR estimates revealed that PMC and non-PMC had no significant difference in SNR (P =0.07). Application of prospective motion correction to 3D-T2-FLAIR sequences decreased the percentage of low-quality scans, reducing the number of scans that need to be repeated to obtain clinically useful data.
March 2018
Reduced brain volumes in children of women with epilepsy: A neuropsychological and voxel based morphometric analysis in pre-adolescent children
Publication date: Available online 2 March 2018
Source:Journal of Neuroradiology Author(s): R.M. Sreedharan, R. Sheelakumari, K.M. Anila, C. Kesavadas, S.V. Thomas Background and purpose Children of Women with Epilepsy with antenatal exposure to antiepileptic drugs (CAED) have reduced neuropsychological functions. We aimed to explore the anatomical basis for this impairment by comparing the brain volumes of CAED with that of matched healthy children without antenatal AED exposure (COAED). Materials and methods CAED aged 8–12 years were recruited from the Kerala Registry of epilepsy and pregnancy that prospectively follows up children of women with epilepsy and COAED from children attending the imaging department for minor illnesses. Maternal clinical details and the neuropsychological data including IQ of CAED and COAED were obtained. Total intracranial volume (TBV), grey matter volume (GMV), white matter volume (WMV) and volumes of deep grey matter were measured by Voxel Based Morphometry. Results We studied 30 CAED (mean age 10.8+1.11 years) and 35 COAED (mean age 10.64+1.26). The antenatal AED exposure for the CAED was monotherapy for 8 children and polytherapy for 22 children. The CAED had significantly lower (P <0.001) IQ (77.5+13.8), TBV(1259.55±169.85mL) and GMV (672.51±85.42 mL) compared to the IQ (87.0+13.5), TBV(1405.37±161mL) and GMV (745.427±86.69 mL) of COAED. CAED had lower volumes for Lt Inferior Triangular Gyrus, and hippocampi on both sides, when compared to COAED. Group analysis CAED showed less GMV (P <0.05) for left inferior and middle frontal gyri relative to COAED. Conclusions These observations point towards an anatomical basis of lower GMV for the lower neuropsychological functions in children with antenatal AED exposure.
March 2018
Editorial Board
Publication date: March 2018
Source:Journal of Neuroradiology, Volume 45, Issue 2

March 2018
Programme des 45e Journ
March 2018
45e Congr
March 2018
Complications du traitement endovasculaire des an

Existe-t-il un b
view: 224

Check out Design Hotels' Mountain Magic deals in places such as the Alps and upstate New York’s Catskill Mountains. Get up to 20% off the best available rate by booking at least 80 days in advance.

Start: 17 Oct 2017 | End: 08 Apr 2018

2nd Price Lower Tier Tickets at the London O2 Arena

Start: 31 May 2017 | End: 08 Mar 2018

BGW Single Day Canadian Residence Offer

Start: 01 Oct 2017 | End: 01 May 2018

Search All Amazon* UK* DE* FR* JP* CA* CN* IT* ES* IN* BR* MX
Booking.com B.V. is based in Amsterdam in the Netherlands. Ready for some statistics? Our 1,534,024 properties, including 860,482 holiday rentals, are located in 123,105 destinations in 229 countries and territories, and are supported internationally by 198 offices in 70 countries.
2013 Copyright © Techhap.com Mobile version 2015 | PeterLife & company
Skimlinks helps publishers monetize editorial content through automated affiliate links for products.
Terms of use Link at is mandatory if site materials are using fully or particulary.
Were treated to the site administrator, a cup of coffee *https://paypal.me/peterlife
Yandex.ru